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br Author contributions br Conflict of interest br Acknowled
2024-01-15
Author contributions Conflict of interest Acknowledgements This work was supported by the National Natural Science Foundation of China (81502276), Major Projects of Science and Technology of Health and Family Planning Commission of Hunan Province (A2017013), the Natural Science Foundation o
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br Increased blood ATX and
2024-01-15
Increased blood ATX and LPA in liver fibrosis Although previous in vitro findings have suggested a link between LPA and liver fibrosis in vivo, whether LPA plays a primary role in the pathogenesis of liver fibrosis has remained uncertain. No phenotypic changes in livers of LPA receptor-deficient
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br Transparency document br Acknowledgments This work has be
2024-01-15
Transparency document Acknowledgments This work has been supported by the National Eye Institute (NIH) Grant 5R01EY023315-02 (MA). This study was also supported in part by National Center for Research Resources Grant S10RR027926 for the lipid analysis and by James and Jean Culver Vision Discov
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br Materials and methods br Results
2024-01-15
Materials and methods Results Discussion Fluoride can readily penetrate cellular membranes and seriously damage the structure and physiological function of cells (Zhou et al., 2015). Several studies have shown that excessive fluoride can decrease the viability of cells and that the growth o
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br Materials and methods br Results br Discussion In
2024-01-15
Materials and methods Results Discussion In this study, we administrated BDE-153 to newborn rat pups at PND 10 and cultured primary neurons, measured neuronal apoptosis and LDH activity in vivo and in vitro, then explored the possible predominant pathway underlying the neuronal apoptosis by
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The reduction of heterodimerization of KOR
2024-01-15
The reduction of heterodimerization of KOR and APJ by both doses of apelin found in the present study may result in inducing protective effects of apelin on the myocardium imposed to high pressure in renovascular hypertension conditions. The finding that apelin in both doses reduced heterodimerizati
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To further address the mechanism of Didox s suppressive
2024-01-15
To further address the mechanism of Didox’s suppressive effects on mast cell activation, FceRI receptor Bromosporine sale and downstream transcription factor induction were assessed. We found that Didox had no effect on FceRI surface expression, and thus concluded that Didox effects must be occurri
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Gene regulation of MMPs is
2024-01-15
Gene regulation of MMPs is influenced by the transcription factor activating factor-1 (AP-1). AP-1 complexes are heterodimers of proteins of the two proto-oncogene families (jun and fos) and have Alisol B 23-acetate in the promoter region of MMPs, as well as in genes mediating inflammatory responses
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br Materials and methods br Results br Discussion Our
2024-01-15
Materials and methods Results Discussion Our results revealed that LPS injection in rats impaired fear memory in the PA task. This results are in agreement with the most of previous studies reported that following acute [23,24,39,[45], [46], [47]] or chronic systemic Pioglitazone HCl sale
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Although many factors influence the effects of medications d
2024-01-15
Although many factors influence the effects of medications, during recent years it has become evident that genetic factors could explain the differences between individuals in drug response. These differences are due to variants in genes encoding drug targets [8]. The challenge for pharmacogenetics
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In addition to differential expression of AR
2024-01-15
In addition to differential expression of AR protein primarily in surgical specimens, genetic alterations involving the AR gene have been documented in human amyloid definition sale cancer. Loss of heterozygosity at the AR locus was identified in all 3 informative cases of muscle-invasive bladder tu
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br Experimental section br Introduction NMDA receptor
2024-01-13
Experimental section Introduction NMDA receptor-induced increases in AMPAR trafficking to the synaptic surface mediates changes in synaptic efficacy in a number of retinoic acid regions (Shi et al., 1999, Sun et al., 2005, Frenkel et al., 2006). While this process has been linked to the regula
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Since all the above vascular and glomerular
2024-01-13
Since all the above vascular and glomerular effects contribute to blood pressure regulation, it is expected for 12/15-LOX pathway to play a role in pathogenesis of hypertension (Fig. 6). Indeed, there is evidence for alterations of the 12- and 15LOX enzymes and metabolites both in humans with essent
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Within the thrombus there is
2024-01-13
Within the thrombus, there is heterogeneity in the activation of nrf2 activator based on the concentration gradients of soluble agonists emanating from the site of vascular injury, which has been excellently reviewed by Tomaiuolo et al.[1]. As part of the coagulation cascade, active thrombin is gen
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Although several studies indicate that ALDH
2024-01-13
Although several studies indicate that ALDH2 protects the heart from injury and maladaptive remodeling (reviewed in [11], [12], [13]), accumulating evidence indicates that deficiency of the enzyme could be protective as well. For example, mice expressing the defective Aldh2*2 mutation show lower ald
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