• Unexpectedly under pathological pain conditions

  2023-11-23

  

  Unexpectedly, under pathological pain conditions, inhibition of spinal glutamate transporter activity can produce antinociceptive effects. For example, intrathecal injection of the transportable inhibitor trans-pyrrolidine-2,4-dicarboxylic Chelerythrine Chloride (t-PDC) or antisense oligonucleotide

• br Experimental procedures br Results br Discussion br Ackno

  2023-11-23

  

  Experimental procedures Results Discussion Acknowledgments Introduction β-Adrenergic receptors (β-ARs) belong to the superfamily of membrane proteins termed G protein-coupled receptors. β-ARs are distributed in the effector GSK621 of most of the sympathetic nerve fibers, and the rece

• Fig A shows a schematic representation of histological

  2023-11-23

  

  Fig. 2A shows a schematic representation of histological results according to the Franklin and Paxinos Mouse Brain Atlas (2001). The black circles represent the sites of drug infusion that were on-target within the amygdala. Gray circles represent the animals that had infusion locations outside the

• Children with ADA SCID commonly

  2023-11-22

  

  Children with ADA-SCID commonly suffer from a variety of opportunistic infections, including viral, fungal, and mycobacterial infections. Due to defects in 2 types of active transport and IG production, they are also susceptible to infection with encapsulated bacteria such as Haemophilus influenzae

• The hippocampus is the primary brain

  2023-11-22

  

  The hippocampus is the primary brain structure involved in learning and memory. The role of hippocampal synaptic plasticity in neurological processes in cognition and depression has been extensively demonstrated. Synaptophysin is a critical substance in synaptogenesis, which is necessary for learnin

• It has also been reported that defects

  2023-11-22

  

  It has also been reported that defects in ATM or ATR signalling are synthetically lethal with PARP inhibition (Turner et al., 2008, Peasland et al., 2011, Yap et al., 2011, Michels et al., 2014), suggesting that combined inhibition of PARP and ATM or ATR may be an effective therapeutic strategy. In

• br Introduction Increased renin angiotensin system RAS

  2023-11-22

  

  Introduction Increased renin-angiotensin system (RAS) activity and inflammation in cardiovascular-related regions of the central nervous system contribute to the overactivity of neurohumoral systems that promote volume retention, cardiac remodeling and serious cardiac arrhythmias in systolic hear

• br Experimental section br Results and discussion

  2023-11-22

  

  Experimental section Results and discussion Conclusion Acknowledgement This work was supported by the National Natural Science Foundation of China (Grant Nos. 81401489), the Shanghai Pujiang Program (17PJ1402800) and the Shanghai Sailing Program (Grant No. 14YF1409000). Introduction

• br Concluding remarks Enhanced membrane binding

  2023-11-22

  

  Concluding remarks Enhanced membrane binding upon calcium stimulation in EPI-001 suggests a pre-requisite step that involves a conformational change in LOX. This might facilitate it to tether to the membrane and regulate enzyme activity. The calcium binding loops and the putative active site entr

• Herein we employ an adapted targeted quantitative

  2023-11-21

  

  Herein we employ an adapted targeted quantitative proteomic isotope dilution method, developed in our laboratory [[18], [19], [20], [21]], to quantify membrane transporters in fresh lung from five donors, in four immortalized human lung cell lines and in three control cell lines. We quantify twelve

• br Hypoadiponectinemia in metabolic syndrome APN belongs str

  2023-11-21

  

  Hypoadiponectinemia in metabolic syndrome APN belongs structurally to the complement 1q family and is found at high concentrations (>0.01% of total protein) in the serum of healthy individuals [6]. Given the abundance of APN in plasma, it is assumed that alterations in plasma levels of APN might

• Angiotensin I (human, mouse, rat) br A novel therapeutic str

  2023-11-21

  

  A novel therapeutic strategy based on the APN and obesity paradoxes As shown above, the relationship of the serum APN concentration with health and disease states shows an inverted-U correlation, suggesting that moderate concentrations of serum APN are beneficial (Fig. 3). Given that both hypo- a

• The overall adjustment the non toxicity and

  2023-11-21

  

  The overall adjustment, the non-toxicity and the addiction-free treatment methods are the advantages of EA. EA treatment for depression has achieved great clinical effect in recent years (Dong et al., 2017). The clinical practice guideline of the American college of physicians (ACP) have pointed out

• Introduction Dementia is a common disease in

  2023-11-21

  

  Introduction Dementia is a common disease in the elderly, and a significant source of disability, healthcare spending, and long-term care admissions. There is evidence to suggest that testosterone plays a role in cognitive functioning, and lower serum levels correlate with higher amyloid deposits (

• br Autophagy inducers Macroautophagy is often

  2023-11-21

  

  Autophagy inducers Macroautophagy is often seen as a cellular process capable of increasing the fitness of na+/ca2+ exchanger and overcome resistance to several forms of stress [9], [10]. As discussed above, it has been proposed by several authors that an effective strategy for enhancing sensiti

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