• Thalidomide is now a well known antiangiogenic agent This pr

  2024-12-27

  

  Thalidomide is now a well known antiangiogenic agent. This property of thalidomide is being extensively researched upon, for its significant utility in the treatment of various malignant tumors. Studies show that thalidomide efficaciously inhibits various pro-angiogenic factors such as tumor necrosi

• We found that decreased Ng levels

  2024-12-27

  

  We found that decreased Ng levels lead to a lower threshold for LTD induction at L4–L2/3 synapses. Previous studies in hippocampal slice culture have shown that LTD at individual synapses induces spine elimination at both the targeted synapse and selective neighboring synapses when spines are monito

• br Material and methods br Results br Discussion

  2024-12-27

  

  Material and methods Results Discussion Aminopeptidase N is a transmembrane protease present in a wide variety of human tissues and cell types (endothelial, epithelial, fibroblast, leukocyte). APN expression is dysregulated in inflammatory diseases as well as in solid and hematologic tumors

• br Concluding remarks Enhanced membrane binding

  2024-12-27

  

  Concluding remarks Enhanced membrane binding upon calcium stimulation in Protease inhibitor cocktail 100X suggests a pre-requisite step that involves a conformational change in LOX. This might facilitate it to tether to the membrane and regulate enzyme activity. The calcium binding loops and the

• br Acknowledgements br Introduction Diabetic complications a

  2024-12-27

  

  Acknowledgements Introduction Diabetic complications are responsible for increased morbidity and mortality of diabetic patients. Increased flow of Plant-derived anthraquinone through the polyol pathway under conditions of hyperglycemia contributes to the development of diabetic complications.

• We found that several anticancer

  2024-12-26

  

  We found that several anticancer drugs inhibit 5-HT3 Luzindole current in vitro. Several studies have suggested that 5-HT3 receptor antagonists have anti-mitogenic and apoptotic effects on colorectal and breast cancer cell lines (Ataee et al., 2010, Hejazi et al., 2015). Irinotecan is used frequent

• The present study showed for the first time that

  2024-12-26

  

  The present study showed, for the first time, that hirsutine, hirsuteine, rhynchophylline, isorhynchophylline, corynoxeine, and isocorynoxeine in yokukansan can inhibit the 5-HT3 receptor current. These data indicate that part of the effect of yokukansan against the behavioral and psychological symp

• Endogenous adenosine systems have largely been implicated in

  2024-12-26

  

  Endogenous adenosine systems have largely been implicated in drug actions by the demonstration that caffeine (non-selective A1R and A2AR antagonist) (see Section The issue of caffeine), in doses up to 7.5–10mg/kg, inhibits antinociception, and when this occurs, it glyoxylic acid monohydrate molecul

• As an alternative to chronic receptor blockade we have

  2024-12-26

  

  As an alternative to chronic receptor blockade, we have been targeting adenosine kinase (ADK) – an astrocyte-based enzyme that catalyses the phosphorylation of adenosine, as a means to modify substance p adenosinergic signalling (Boison, 2006, Etherington et al., 2009). Up-regulating ADK facilitate

• Some alterations in the integrity of cell membranes caused

  2024-12-26

  

  Some alterations in the integrity of cell membranes caused by toxic agents can be determined by measuring certain enzymes released by damaged cells [8]. The cholinesterases, for example, catalyze the hydrolysis of Antioxidant flavonoid (ACh) in choline and acetic acid. Theses enzymes are divided int

• DNA polymerase inhibitor br Conclusions The following are th

  2024-12-26

  

  Conclusions The following are the supplementary data related to this article. Author contributions Conflict of interest Funding sources This work was supported by the Canadian Institutes of Health Research [grant: MOP-79470]. Introduction Sperm cells undergo a number of physical and

• Most studies on d penicillamine

  2024-12-26

  

  Most studies on d-penicillamine-induced MG were performed before the discovery that some MG patients have anti-MuSK antibodies. After the identification of the present case, we retrospectively tested the stored frozen sera of ten earlier identified d-penicillamine MG patients with anti-AChR BMS-8339

• what is doxepin hydrochloride cream used for Although experi

  2024-12-26

  

  Although experiments on animals and cells indicate that antioxidant and free radical scavenging agents have protective effects against brain damage, the results of preclinical trials are not as encouraging. Edaravone is a type of free radical scavenging drug that was first used as a neuroprotective

• The anorexic effect observed when AR

  2024-12-26

  

  The anorexic effect observed when AR231630 is infused into the VTA could be the result of the DA release inhibition, as previously described [11]. However, there is also a hedonic aspect in feeding that possibly involves dopaminergic mechanisms of reward. Helm et al. showed a functional link between

• lp-pla2 inhibitor br Materials and methods br Results To exp

  2024-12-26

  

  Materials and methods Results To explore the potential role of autophagy in drug resistance, we firstly performed immunohistochemistry to compare the lp-pla2 inhibitor of p62 in paired primary, metastatic, and recurrent tumor tissues from 26 ovarian cancer patients. The expression of p62 was

14723 records 31/982 page Previous Next First page 上5页 3132333435 下5页 Last page