• Recently a G protein coupled

  2022-09-09

  

  Recently, a G-protein-coupled receptor, GPR109a, was identified as a molecular target for niacin. Mechanistic studies have suggested that the benefits of niacin therapy may result from the activation of GPR109a located on adipocytes. Recent experiments have shown that niacin activation of GPR109a re

• The importance of FXR FGF signaling in BA

  2022-09-09

  

  The importance of FXR-FGF15/19 signaling in BA homeostasis is illustrated by various BA malabsorption syndromes. Clinically, BA malabsorption causes diarrhea due to high BA concentrations in the colon that lead to secretion of water and electrolytes and stimulation of propulsive contractions [36]. P

• Abnormal expression and higher activity of GLO I have been

  2022-09-09

  

  Abnormal expression and higher activity of GLO I have been detected more in various tumor f4 cat than in normal cell samples., , , , , , , Among cancer cell lines, lung carcinoma cells frequently showed higher GLO1 activity. Human NSCLC cell line NCI-H522 cells possess high activity and expression o

• br Introduction L Glutamate is

  2022-09-09

  

  Introduction L-Glutamate is one of the most prevalent excitatory signaling molecules in the central nervous system (CNS) (Salazar et al., 2016) and plays a crucial role in a variety of fluoxetine hydrochloride sale functions such as memory and learning (Danbolt, 2001, Nedergaard et al., 2002). A

• MicroRNA or miRNA is group of

  2022-09-09

  

  MicroRNA, or miRNA, is group of RNA molecule of about 22 nucleotides without protein-coding function. MicroRNAs are widely distributed in plants, animals and even some viruses and participant in both normal physiological and pathological processes by post-transcriptional regulation of gene expressio

• In Solloway and colleagues reported that mice with alpha

  2022-09-09

  

  In 2015, Solloway and colleagues reported that mice with alpha cell hyperplasia due to inactive hepatic glucagon receptor signaling may most likely be caused by amino Fumagillin receptor dependent mechanisms [11]. The authors then showed these adaptations are regulated by ‘mechanistic target of rap

• In this study we demonstrate that

  2022-09-09

  

  In this study, we demonstrate that the ETS transcription factor ETV5 is involved in the regulation of ghrelin system in response to the altered nutritional state. In the recent multiple GWAS studies, three single nucleotide polymorphisms (SNPs) of ETV5, rs7647305 (Thorleifsson et al., 2009; Willer e

• Hypertriglyceridemia is associated with an overproduction an

  2022-09-09

  

  Hypertriglyceridemia is associated with an overproduction and secretion of triglyceride-rich lipoproteins (TRLs), due to increased liver lipid substrate availability (Adiels et al., 2005, Choi and Ginsberg, 2011), and/or reduced catabolism of TRLs and their remnants, due to reduced lipoprotein lipas

• Comparison of dlGALRs deduced amino acid

  2022-09-09

  

  Comparison of dlGALRs deduced amino Neurotensin sequences with that of human GALRs demonstrate that the GALR1 ortholog sequences have diverged less than those of GALR2. Since often duplicate genes undergo divergent evolution through sub-functionalization, loss or gain of new functions (Prince and Pi

• In addition we assessed the

  2022-09-09

  

  In addition, we assessed the viability of 1,2,3,4-tetrahydroquinoline (13t) and 1,2,3,4-tetrahydroisoquinoline (13u) as the tail on account of our previous SAR results. To our delight, 13t and 13u each had comparable activity to that of 13c, with 13u being slightly more potent than 13c. Further stru

• Remarkably most of these molecules are

  2022-09-09

  

  Remarkably, most of these molecules are also quite effective in interfering with the proliferation of the drug-resistant cancer cell lines, with IC50 values ranging from 0.59 to 2.93 μM against MCF-7/ADR cells, and from 0.160 to 1.17 μM against NSCLC-resistant H1975 cells. Among these molecules, com

• Compared to the other histamine receptor

  2022-09-08

  

  Compared to the other oxygenase receptor subtypes, the H3 receptor exhibits rather complex pharmacology, being subject to extensive splicing, leading to two major (H3-445 and H3-365) and possibly more functional human receptor isoforms; for a comprehensive review please see Leurs et al. (2005) and

• The Hippo pathway is a growth

  2022-09-08

  

  The Hippo pathway is a growth control signaling cascade that has been demonstrated to play an important role in regulating cell proliferation and differentiation [5,6]. The core signaling pathway consists of a group of kinases which negatively regulate the expression of transcriptional co-activators

• br Materials and methods br Results

  2022-09-08

  

  Materials and methods Results Discussion The innate immune system plays an important role in protecting against IAV infections. However, the virus has the ability of escaping the innate immune system. Activating or enhancing an innate immune response before or during a viral infection will

• br sGC cGMP PKG pathway in regulation of platelet small

  2022-09-08

  

  sGC/cGMP/PKG pathway in regulation of platelet small GTPases All classical Rho family members of small GTPases including RhoA, Rac, Cdc42, some atypical Rho GTPases like RhoB, RhoF and RhoG, and also Ras family members N-Ras, K-Ras, Rap1A, Rap1B, Rap2A and Rap2B, and the Ras-related GTPases of th

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