• Growing evidence suggests that the glycine site

  2022-06-14

  

  Growing evidence suggests that the glycine site seems to play a pivotal role in NMDAR-related function. For example, it 172 3 has been demonstrated in a hippocampal slice study that the glycine site sub-serves the spatiotemporal detection of synaptic activity (Li et al., 2009). Moreover, mice with

• br Methods and materials br Results

  2022-06-14

  

  Methods and materials Results Overall, free glutamate intakes in US children and adults are shown in Table 1. The sample-weighted mean intake of crude free glutamate was 258 mg/d for children and 322 mg/d for adults. Furthermore, the corresponding energy-adjusted value was 136 mg/1000 kcal and

• br Funding This work was

  2022-06-14

  

  Funding This work was supported by grants of the National Academy of Sciences of Ukraine within the programs “Molecular and cellular biotechnologies for medicine, industry and agriculture” (#35-2018), “Scientific Space Research for 2018-2022” (#19-2018), “Smart sensory devices of a new generation

• To further implicate the role of EAAT in

  2022-06-14

  

  To further implicate the role of EAAT3 in morphine-induced place preference, the effects of morphine on EAAT3 Raloxifene HCl was determined. Interestingly, morphine increased EAAT3 protein expression in the plasma membrane of mPFC, nucleus accumbens and VTA but not in the hippocampus of wild-type m

• br Experimental methods br Acknowledgments We thank all memb

  2022-06-14

  

  Experimental methods Acknowledgments We thank all members of the Hermanson lab, especially Ana Teixeira, Shirin Ilkhanizadeh and Karolina Wallenborg, for assistance and discussions, Peter Löw for anti-synaptotagmin antibody, and Lars Björklund, Ole Isacson, Christer Höög, Claes Wahlestedt and

• br Conclusion and future directions GS

  2022-06-14

  

  Conclusion and future directions GS is an important therapeutic target for the treatment of Alzheimer's disease. Its structure and function have been studied during the last years to understand the substrate cleavage mechanism to modulate the Aβ42 peptide production. The recent elucidation of GS

• The stability of the i motif at the

  2022-06-14

  

  The stability of the i-motif at the neutral pH has been analyzed in our previous paper [31] by tracking the rmsd changes in unbiased calculations. Fig. 7 presents, just to confirm the conclusions drawn in [12], the changes in distances between atoms forming hydrogen bonds within the i-motif structur

• br Financial support This work was supported

  2022-06-14

  

  Financial support This work was supported by Fondation pour la Recherche Médicale (Equipe labellisée, DEQ20150331724), Inserm, University of Lille, and Agence Nationale pour la Recherche (ANR-10-LBEX-46 and ANR-10-INBS-08; ProFI project, “Infrastructures Nationales en Biologie et Santé”; “Investi

• br Acknowledgements We thank Dr Bhushan

  2022-06-14

  

  Acknowledgements We thank Dr. Bhushan Nagar and Dr. Albert Berghuis for access to the X-ray diffraction machine at McGill University. We also thank Dr. Manon Couture and Dr. Steve Charette at Université Laval for access to scientific equipment. Funding for this research was provided by Discovery

• It should be noted that

  2022-06-14

  

  It should be noted that the current studies were performed in female rats. Although the oestrous cycle has been shown to modulate inflammatory processes in the periphery, data from our group has demonstrated that the phase of the oestrus cycle does not significantly alter TLR3-mediated neuroinflamma

• br Materials and methods br Results br

  2022-06-14

  

  Materials and methods Results Discussion mmLDL is an important risk factor for cardiovascular disease, but its mechanism is still unclear. Previously, we co-cultured mmLDL with the coronary artery and basilar artery and found that mmLDL could upregulate ETB receptor expression in both [16],

• The IN gene of the HIV

  2022-06-13

  

  The IN gene of the HIV isolate from Papua (CRF01_AE isolate) contains genetic polymorphisms (Fig. 1A) that encode for variant amino acids in the IN protein, based on the Stanford HIVdb mutation interpretation database (Fig. 1B). These variations slightly changed the three-dimensional structure of IN

• br Introduction Ovarian cancer patients

  2022-06-13

  

  Introduction Ovarian cancer patients have the highest mortality rate amongst patients with gynecologic cancers. The 10-year survival rate of ovarian cancer patients is 5-Formyl-CTP australia with BRCA1/2 mutation [2]. Several studies have indicated the role of dysregulation of histone methylati

• It is difficult however to assure that observed alterations

  2022-06-13

  

  It is difficult, however, to assure that observed alterations of pro-oxidant/antioxidant levels within the studied organisms are related directly to heavy metal pollution, rather than to other accompanying environmental stressors. Environmental factors like oxygen partial pressure, temperature, sali

• br Introduction br Mitochondrial dysfunction and cancer

  2022-06-13

  

  Introduction Mitochondrial dysfunction and cancer Lactate and succinate as oncometabolites Intracellular actions of lactate and succinate as tumor promoters Cell-surface receptors for lactate and succinate and their role in cancer GPR109A as the receptor for butyrate and β-hydroxybu

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