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MicroRNA or miRNA is group of RNA molecule of about
2022-02-08
MicroRNA, or miRNA, is group of RNA molecule of about 22 nucleotides without protein-coding function. MicroRNAs are widely distributed in plants, animals and even some viruses and participant in both normal physiological and pathological processes by post-transcriptional regulation of gene expressio
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It has been reported that the pathway upstream
2022-02-08
It has been reported that the pathway upstream of YAP phosphorylation is operative in a tissue or context-specific manner. LPA or S1P bound to their corresponding membrane GPCRs and act through Rho GTPases to activate YAP/TAZ [11]. Consistently, another report showed that activation of PAR1 (a GPCR)
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The third group also included samples belonging
2022-02-08
The third group also included samples belonging to subjects with undetectable viraemia, for which the negative or persistence of the indeterminate WB result in subsequent samples indicated a non-HIV infection. In this subgroup, the VITROS HIV Combo test (as well as the other two tests) was negative
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br STAR Methods br Acknowledgments We thank
2022-02-08
STAR★Methods Acknowledgments We thank Emeritus Professor Chikashi Shimoda and Professor Taro Nakamura of the National BioResource Project/Yeast Genetic Resource Center (NBRP/YGRC) at Osaka City University (Osaka, Japan) for Schizosaccharomyces pombe meiotic cDNA library, yeast plasmids, yeast
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In conclusion the most salient observation
2022-02-08
In conclusion, the most salient observation from this study was that PAE reduced the expression of HDC protein expression in dentate gyrus, cerebral cortex, and cerebellum, but not in the caudate nucleus or ventral hypothalamus. The regional basis for this heightened sensitivity is not known, but it
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HCV NS A inhibits induction of the
2022-02-08
HCV NS3/4A inhibits induction of the type I interferon response by cleaving MAVS from the mitochondrial surface (Li et al., 2005b). MAVS is cleaved at cysteine 508, and Tariquidar methanesulfonate, hydrate of cysteine 508 to arginine (C508R) abrogates cleavage (Li et al., 2005b). GBV-B and the rela
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Furthermore we observed a striking difference between BR and
2022-02-08
Furthermore, we observed a striking difference between BR 11257 and activators from the dicarboxylic Phosphatase Inhibitor Cocktail 2 (100X in ddH2O) type in thermofluor measurements on thermostability. The dicarboxylic acids cinaciguat [30] and BAY 60-2770 (see Fig. 3) induced a significant melting
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NCSs are helical proteins containing four EF
2022-02-08
NCSs are α-helical proteins containing four EF-hand motifs with EF1 being incapable of Ca-binding throughout the family (atomic-resolution structure was firstly resolved for recoverin [5]; for review on NCS structure, see [6]). Some of the NCS proteins (i.e. recoverin and KChIP3) have two while othe
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Here we used Drosophila and mouse
2022-02-08
Here, we used Drosophila and mouse models to address the biological function of RALs in the adult intestine. Our results demonstrate a conserved in vivo role for RALs in ISC function during tissue homeostasis and regeneration. ISCs lacking RALs were at a disadvantage compared to wild-type neighbors.
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br Conclusion The development discovery of compounds targeti
2022-02-08
Conclusion The development/discovery of compounds targeting small GTPases is challenging [43,44]. Our data point to RBC8 being efficient and potent as a Ral inhibitor in human and mouse platelets, but that it exhibits some activity beyond just Rals, particularly in mouse platelets. It is however
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br GSNOR regulates SA synthesis and SA
2022-02-08
GSNOR1 regulates SA synthesis and SA signalling The phenolic metabolite salicylic KW 2449 receptor (SA) is a powerful immune activator in plants. Moreover, mutations that disable SA biosynthesis or transgenes that result in its depletion compromise both resistance (R) gene-mediated and basal resi
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GnRH ant have been designed to obtain pharmacological compou
2022-02-07
GnRH-ant have been designed to obtain pharmacological compounds to block the pituitary–gonadal axis without the undesirable flare effect exerted by GnRH itself or by the GnRH-a (see Section 2.2). GnRH-ant competitively block the binding of GnRH to GnRHRs (Schally, 1999; Tan & Bukulmez, 2011); they p
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In the present study administration of both
2022-02-07
In the present study, administration of both muscimol and bicuculline also affected the biosynthesis of GnRHR. A significant decrease in GnRHR level in the POA, AH, VMH and SME following muscimol treatment as well as the opposite effect induced by bicuculline indicates that GnRHR gene expression is,
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br Materials and methods br Results
2022-02-07
Materials and methods Results Discussion The GO system is an important mechanism for maintaining the integrity of genetic material in many eukaryotic organisms. This is demonstrated by the high conservation, across different evolutionary lineages, of the sequences of the proteins that compo
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Capillary monolithic columns obtained by
2022-02-07
Capillary monolithic columns obtained by in situ polymerization have been developed rapidly as an efficient chromatographic stationary phase, which exhibits excellent reproducibility, reliable stability and fast transfer kinetics [18]. Recently, it has been extensively applied in capillary liquid ch
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