• The intracellular signaling that mediates the adipogenesis i

  2021-12-14

  

  The intracellular signaling that mediates the adipogenesis induced by GPR120 still remains largely unknown. In the present study we showed that TUG-891 induced the activation of [Ca2+]i and ERK1/2 signaling in 3T3-L1 cells. Moreover, incubation of TUG-891 combined with BAPTA-AM or U0126 abolished TU

• In order to investigate whether this off

  2021-12-14

  

  In order to investigate whether this off-target activity was related to a particular structural feature of this L-a-Hydroxyglutaric acid disodium salt or was characteristic of the series, compounds , and were selected as being matched pairs with compound but with structural variation in terms of the

• With an ever increasing incidence rate of type diabetes and

  2021-12-14

  

  With an ever-increasing incidence rate of type 2 diabetes and obesity, it is imperative to develop new therapeutic regimes that may provide a benefit both in terms of efficacy and tolerability. The existing portfolio of drugs for the treatment of metabolic disorders, primarily type 2 diabetes and ob

• The use of HIV peptide epitope based

  2021-12-14

  

  The use of HIV-1 peptide epitope-based vaccines is safer and cheaper than live or inactivated vaccines [8]. However, peptide epitope vaccines could show poor immunogenicity and have poor uptake by APCs [9]. Nevertheless, nanocarrier-based delivery platforms have been demonstrated to enhance the pept

• br Conclusion br Experimental procedures br Introduction The

  2021-12-14

  

  Conclusion Experimental procedures Introduction The glycine receptor (GlyR) is a member of the Cys-loop family of ligand-gated ion channels. It is the primary inhibitory receptor in the brainstem and spinal cord but also plays important roles in higher LDN193189 Hydrochloride regions, incl

• br Materials and methods br

  2021-12-14

  

  Materials and methods Results In this study we re-examined the kinetics of ET transport and tested the ability of various suggested substrates of OCNT1 to inhibit ET uptake. Using a native ET transporter expressed in the human HeLa cell line ET was found to be taken up with a Km of 51 μM and V

• Previous attempts to minimize the

  2021-12-14

  

  Previous attempts to minimize the contribution of the compensatory changes due to chronic loss of Gcgr, have used temporally-controlled reduction of glucagon levels by alpha-cell ablation, glucagon immunoneutralization, and the use of small molecule or antibody glucagon receptor antagonists [10], [3

• Actinomycin D The HH signaling has also been implicated in t

  2021-12-14

  

  The HH signaling has also been implicated in the regulation of cancer stem Actinomycin D (CSC) by promoting their self-renewal [53]. Activated HH signaling has been identified in CSCs of many solid tumors, such as glioblastoma, breast, colon, pancreatic cancer, melanoma, and hematological malignanc

• br Electron crystallographic structures of connexins The str

  2021-12-14

  

  Electron crystallographic structures of connexins The structures of gap junctions are good targets for electron microscopy because they exhibit the characteristic features of self-assembly. Early studies examined the three-dimensional (3D) structures of native gap junction LBH589 from rodents us

• First identified in as the

  2021-12-14

  

  First identified in 1982 as the second mammalian glutathione peroxidase [23], we and Stockwell's group demonstrated in 2014 that the selenoperoxidase GPX4 is the key upstream regulator of ferroptosis [12], [13]. The role of GPX4 as the main regulator in the ferroptotic process is based on its unique

• The mechanistic basis of a PAE induced reduction in HDC

  2021-12-13

  

  The mechanistic basis of a PAE-induced reduction in HDC isoform expression is unclear at present. These reductions may be a consequence of reduced histaminergic innervation of PAE-affected brain regions. Given that these three brain regions are anatomically more distant from the ventral hypothalamus

• While the dogma of the mainstream

  2021-12-13

  

  While the dogma of the mainstream considers Hippo pathway as a series of size-controlling kinases, there were still some controversial data supporting that YAP, a vital oncoprotein of Hippo downstream, is antagonistic to regenerative proliferation [[20], [21], [22]]. Known for its expansion-driving

• It would also be interesting to understand the

  2021-12-13

  

  It would also be interesting to understand the potential connection between asymmetric histone inheritance and another phenomenon reported by several investigators: selective DNA strand segregation (reviewed by Evano and Tajbakhsh, 2013, Rando, 2007, Tajbakhsh and Gonzalez, 2009). Recent development

• In contrast to sGC stimulators sGC activators

  2021-12-13

  

  In contrast to sGC stimulators, sGC activators promote enzymatic activity of sGC containing oxidized heme iron (Fe3+) or missing the heme group. A-350619 is one of the oldest activators of sGC to be discovered. A-350619 increased sGC activation in a non-additive manner with respect to YC-1, leading

• To apply the recently developed GPR ligands

  2021-12-13

  

  To apply the recently developed GPR35 ligands to CNS disorders, it is necessary to understand whether GPR35 is expressed by any identified cell types in the Ertapenem sodium salt and whether activation or blockade of this receptor has any consequence on the activity of the neuronal circuitry. To th

14777 records 519/986 page Previous Next First page 上5页 516517518519520 下5页 Last page