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The intimate interactions between flavonoids and ER
2019-09-09
The intimate interactions between flavonoids and ERα have been more extensively studied than their ERβ interactions because of the dominant role of ERα in some important diseases (Ye et al., 2018) including breast cancer (more than 80% of human breast cancers are ERα positive) (Turner et al., 2015),
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Previously to detect CDKL activity we used a radioactive
2019-09-07
Previously, to detect CDKL5 activity, we used a radioactive phosphorylation assay with amphiphysin 1 protein as a substrate [,,]. However, it is necessary to establish a safe and rapid method for analyzing CDKL5 mutant activity. Here, we report a new method for investigating autophosphorylation acti
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The identification of a functional leucine rich NES mediatin
2019-09-07
The identification of a functional leucine-rich NES mediating 8E7 nuclear export led us to analyze the interaction between 8E7 and CRM1 nuclear export receptor. HeLa cell lysates containing EGFP-8E7, EGFP–8cE7, EGFP-16E7–NES (as a positive control), or EGFP (as a negative control) were incubated wit
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Since inception of the accelerated program in California has
2019-09-07
Since inception of the accelerated program in 2000, California has varied the requirements for CPA licensure. Prior to 2002, licensure was available with a bachelor’s degree in any subject, 24 semester hours (36 quarter units) of accounting, 24 semester hours (36 quarter units) of general business,
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all trans retinoic acid and From materials science it is
2019-09-07
From materials science, it is known that the differences in the annealing temperature is the main factor that mostly influences La (Takai et al., 2003, Cançado et al., 2006). In analogy, controlling the pyrolysis temperature and all trans retinoic acid and during residues burning might be a key asp
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COMT protein expression was investigated as
2019-09-07
COMT protein TIC10 was investigated as a potential mechanism by which tolcapone may differentially affect male and female P and Wistar rats. COMT protein levels in the PFC were lower in P rats compared to Wistars but female P rats expressed greater levels of COMT in the PFC relative to males. Engle
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However not all inhibitory profiles by metals can be a
2019-09-07
However, not all inhibitory profiles by metals can be a priori considered artifacts of the methodology used to quantify the activity of such enzymes. Metals can indeed interfere with cholinesterases, and the mechanisms are varied. The inhibitory effect of specific metals may derive from their abilit
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br Author Contributions br Funding Canadian Institutes of He
2019-09-07
Author Contributions Funding Canadian Institutes of Health Research, operating grant NMD-83126 and the internal funding from the National Research Council Canada, Charlottetown, PE, Canada. Disclosure Statement Acknowledgements Introduction Cholesterol is an essential structural comp
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MSCs are self renewing multipotent progenitor cells with
2019-09-07
MSCs are self-renewing, multipotent progenitor cells, with multilineage potential to differentiate into adipocytes, osteocytes, and chondrocytes. In addition, MSCs can migrate to sites of inflammation, supporting hematopoiesis and homeostatic maintenance. Given their unique therapeutic properties, M
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The optimization of the lead
2019-09-07
The optimization of the lead compound () was initiated and the initial key SAR and the results of the structural modifications of lead compound are summarized in . Replacement of the carboxylic exendin 4 moiety with other functional groups led to loss of functional activity against EP4 receptor. A
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br Methods br Results br Discussion
2019-09-07
Methods Results Discussion I/R induces oxidative stress and increases the intracellular levels of ROS, resulting in tissue damage [31]. ROS is generated by mitochondrial electron transport chain, nicotinamide Swainsonine dinucleotide phosphate (NADPH) oxidase complex, xanthine oxidase and
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ITF 2357 ELUXA HM EMSI is an ongoing pivotal Phase
2019-09-07
ELUXA 1 (HM-EMSI-202) is an ongoing pivotal Phase II global clinical trial, designed to further investigate the efficacy and safety of Olmutinib in patients T790M-positive NSCLC with acquired resistance after first-line EGFR TKIs. Primary endpoint is ORR according to RECIST 1.1, while secondary endp
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br Significance Our understanding of the ubiquitin biology h
2019-09-07
Significance Our understanding of the ubiquitin biology has been rapidly expanding. The role of the ubiquitin system in the pathogenesis of numerous disease states has increased the interest in finding new strategies to pharmacologically interfere with the enzymes responsible of the ubiquitinatio
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br Results br Discussion The nitric oxide
2019-09-06
Results Discussion The nitric oxide-cyclic guanosine monophosphate pathway plays an important role in normal EF, and oral PDE-5Is were developed in the late 90s after the discovery that ED occurs when there is a problem with this pathway. Since then, several PDF-5Is with different pharmacokine
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br Conflicts of interest br Author contributions br Acknowle
2019-09-06
Conflicts of interest Author contributions Acknowledgements This work was supported by the University of Brescia (ex 60%) and Siderurgica Leonessa research funds to AF. RR was supported by Associazione Italiana per la Ricerca sul Cancro - AIRC (MFAG 18459 grant). We are grateful to Umberto
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